Thankfully, you can get help overcoming addiction and drug abuse before long-term harm occurs. The actual article says that overdosing on Tylenol is dangerous if you drink alcohol. Acetaminophen is probably the riskiest painkiller to take while drinking. For alcoholics, acetaminophen-containing drugs such as Tylenol can be dangerous. The headline is misleading. Too much Tylenol can damage your liver and cause serious illness or death. Mixing alcohol and codeine, or any other combination of intoxicating substances, can lead to addiction and dependence. Take acetaminophen with alcohol can also hurt liver. The amount of alcohol you drink (alcohol can increase the production of toxic NAPQI) If you take other medications with Tylenol. When this enzyme comes into contact with the acetaminophen, a toxic substance called NAPQI will be created, which can kill liver cells. In general, adults can take between 650 milligrams (mg) and 1,000 mg of acetaminophen every 4 to 6 hours. Both have an adverse effect on the liver. WDSU Medical Editor Dr. Corey Hebert talks about how sleeping pills and Tylenol could affect you. Together they can cause diver damage or even death but it would have to be large doses or over a long period of time. According to one National Institutes of Health publication on alcohol and metabolism , liver damage effects may occur with as little of four to five "extra-strength" pills taken over the course of the day in people who consumed varying amounts of alcohol. Alcohol can do the same thing over time. Some drugs, including opiods, dilantin, and others, may interact poorly with Tylenol and increase the risk of liver damage; certain herbal supplements can also interact with Tylenol and cause liver damage. Doctors warn about side effects of sleeping pills and Tylenol. Read the directions on the bottle OTC pain medications: "One of the worst is acetaminophen," says Dr. MacKinnon. Acetaminophen (Tylenol) Photo courtesy of Wikimedia Commons. 2E1 enzyme is an enzyme that is produced in the liver as a result of sustained drinking over a few days. 1. A new study suggests that people who take the correct dose of acetaminophen, combined with a even a small amount of alcohol, have a 123 percent greater chance of getting kidney disease — yes, that's not a typo. You can take Tylenol for hangovers. Doctors have known for many years that alcoholics (6+ drinks per day) should not take Tylenol and people who take the maximum dose of tylenol on a daily basis should not drink. Acetaminophen, also known as paracetamol or Tylenol, is a drug that people use to treat mild-to-moderate pain and fever.. Recovery is possible for anyone. Acetaminophen and Alcohol: Liver Damage. Alcohol can cloud judgment and impair impulse control, making overdose more likely. Tylenol is relatively safe when you take the recommended dose. 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